T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of Prx1 at Ser-32 Prevents UVB-induced Apoptosis in RPMI7951 Melanoma Cells through the Regulation of Prx1 Peroxidase Activity

Protein kinases are potential targets for the prevention and control of UV-induced skin cancer. T-cell-originated protein kinase (TOPK) is highly expressed in skin cancer cells, but its specific function is still unknown. We investigated the role of TOPK in UVB-induced apoptosis in RPMI7951 human me...

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Bibliographic Details
Main Authors: Zykova, Tatyana A., Zhu, Feng, Vakorina, Tatyana I., Zhang, Jishuai, Higgins, Lee Ann, Urusova, Darya V., Bode, Ann M., Dong, Zigang
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937944/
https://ncbi.nlm.nih.gov/pubmed/20647304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.135905
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