Mammalian Telomeric DNA Suppresses Endotoxin-induced Uveitis

Telomeric regions of mammalian chromosomes contain suppressive TTAGGG motifs that inhibit several proinflammatory and Th1-biased immune responses. Synthetic oligodeoxynucleotides (ODN) expressing suppressive motifs can reproduce the down-regulatory activity of mammalian telomeric repeats and have pr...

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Detalhes bibliográficos
Main Authors: Yagci, Fuat C., Aslan, Ozlem, Gursel, Mayda, Tincer, Gizem, Özdamar, Yasemin, Karatepe, Kutay, Akcali, K. Can, Gursel, Ihsan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937908/
https://ncbi.nlm.nih.gov/pubmed/20630869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.125948
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