Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response.

Nitric oxide (NO)-dependent cyclic guanosine monophosphate (cGMP) generation was examined in glomeruli isolated from 1-2-wk and 2-mo streptozotocin diabetic (D) and control (C) rats. After 1-2 wk of diabetes, ex vivo basal cGMP generation and cGMP responses to carbamylcholine (CCh) were significantl...

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Vydáno v:J Clin Invest
Hlavní autoři: Craven, P A, Studer, R K, DeRubertis, F R
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 1994
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293768/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7506712/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116961
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