Dominant Negative Mutants of the Murine Cytomegalovirus M53 Gene Block Nuclear Egress and Inhibit Capsid Maturation

The alphaherpesvirus proteins UL31 and UL34 and their homologues in other herpesvirus subfamilies cooperate at the nuclear membrane in the export of nascent herpesvirus capsids. We studied the respective betaherpesvirus proteins M53 and M50 in mouse cytomegalovirus (MCMV). Recently, we established a...

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Bibliographic Details
Main Authors: Popa, Mirela, Ruzsics, Zsolt, Lötzerich, Mark, Dölken, Lars, Buser, Christopher, Walther, Paul, Koszinowski, Ulrich H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937598/
https://ncbi.nlm.nih.gov/pubmed/20610730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00681-10
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