Dominant Negative Mutants of the Murine Cytomegalovirus M53 Gene Block Nuclear Egress and Inhibit Capsid Maturation

The alphaherpesvirus proteins UL31 and UL34 and their homologues in other herpesvirus subfamilies cooperate at the nuclear membrane in the export of nascent herpesvirus capsids. We studied the respective betaherpesvirus proteins M53 and M50 in mouse cytomegalovirus (MCMV). Recently, we established a...

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Autori principali: Popa, Mirela, Ruzsics, Zsolt, Lötzerich, Mark, Dölken, Lars, Buser, Christopher, Walther, Paul, Koszinowski, Ulrich H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937598/
https://ncbi.nlm.nih.gov/pubmed/20610730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00681-10
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