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Human Pat1b Connects Deadenylation with mRNA Decapping and Controls the Assembly of Processing Bodies

In eukaryotic cells, degradation of many mRNAs is initiated by removal of the poly(A) tail followed by decapping and 5′-3′ exonucleolytic decay. Although the order of these events is well established, we are still lacking a mechanistic understanding of how deadenylation and decapping are linked. In...

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Hlavní autoři: Ozgur, Sevim, Chekulaeva, Marina, Stoecklin, Georg
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937563/
https://ncbi.nlm.nih.gov/pubmed/20584987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00429-10
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