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Myristoylation and Membrane Binding Regulate c-Src Stability and Kinase Activity
Myristoylation is critical for membrane association of Src kinases, but a role for myristate in regulating other aspects of Src biology has not been explored. In the c-Abl tyrosine kinase, myristate binds within a hydrophobic pocket at the base of the kinase domain and latches the protein into an au...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology (ASM)
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2937550/ https://ncbi.nlm.nih.gov/pubmed/20584982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00246-10 |
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