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Myristoylation and Membrane Binding Regulate c-Src Stability and Kinase Activity

Myristoylation is critical for membrane association of Src kinases, but a role for myristate in regulating other aspects of Src biology has not been explored. In the c-Abl tyrosine kinase, myristate binds within a hydrophobic pocket at the base of the kinase domain and latches the protein into an au...

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Библиографические подробности
Главные авторы: Patwardhan, Parag, Resh, Marilyn D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937550/
https://ncbi.nlm.nih.gov/pubmed/20584982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00246-10
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