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Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1.

Adhesion of leukocytes to endothelial cells is a critical step in the development of acute and chronic inflammatory lesions. We report here that estradiol treatment of cultured human umbilical vein endothelial cells stimulated up to a twofold increase in TNF-induced adhesion of both polymorphonuclea...

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Udgivet i:J Clin Invest
Principais autores: Cid, M C, Kleinman, H K, Grant, D S, Schnaper, H W, Fauci, A S, Hoffman, G S
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293714/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7506711/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116941
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