Functional Assays for Classification of BRCA2 Variants of Uncertain Significance

The assessment of the influence of many rare BRCA2 missense mutations on cancer risk has proved difficult. A multifactorial likelihood model that predicts the odds of cancer causality for missense variants is effective, but is limited by the availability of family data. As an alternative, we develop...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Farrugia, Daniel J., Agarwal, Mukesh K., Pankratz, Vernon S., Deffenbaugh, Amie M., Pruss, Dmitry, Frye, Cynthia, Wadum, Linda, Johnson, Kiley, Mentlick, Jennifer, Tavtigian, Sean V., Goldgar, David E., Couch, Fergus J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936780/
https://ncbi.nlm.nih.gov/pubmed/18451181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-1587
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares