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Fine-tuning of neuronal architecture requires two profilin isoforms

Two profilin isoforms (PFN1 and PFN2a) are expressed in the mammalian brain. Although profilins are essential for regulating actin dynamics in general, the specific role of these isoforms in neurons has remained elusive. We show that knockdown of the neuron-specific PFN2a results in a significant re...

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Détails bibliographiques
Auteurs principaux: Michaelsen, Kristin, Murk, Kai, Zagrebelsky, Marta, Dreznjak, Anita, Jockusch, Brigitte M., Rothkegel, Martin, Korte, Martin
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2010
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936622/
https://ncbi.nlm.nih.gov/pubmed/20798032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004406107
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