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Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins

BACKGROUND: Whereas T cell receptors (TCRs) detect peptide/major histocompatibility complexes (pMHCs) with exquisite specificity, there are challenges regarding their expression and use as soluble detection molecules due to molecular instability. We have investigated strategies for the production of...

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Detalhes bibliográficos
Main Authors: Lunde, Elin, Løset, Geir Åge, Bogen, Bjarne, Sandlie, Inger
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936418/
https://ncbi.nlm.nih.gov/pubmed/20735812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-10-61
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