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Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins
BACKGROUND: Whereas T cell receptors (TCRs) detect peptide/major histocompatibility complexes (pMHCs) with exquisite specificity, there are challenges regarding their expression and use as soluble detection molecules due to molecular instability. We have investigated strategies for the production of...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2936418/ https://ncbi.nlm.nih.gov/pubmed/20735812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-10-61 |
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