Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats

BACKGROUND: Temporomandibular disorders (TMDs) are characterized by persistent orofacial pain and have diverse etiologic factors that are not well understood. It is thought that central sensitization leads to neuronal hyperexcitability and contributes to hyperalgesia and spontaneous pain. Nonsteroid...

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Autori principali: Xu, Wen, Wu, Yuwei, Bi, Yeping, Tan, Lei, Gan, Yehua, Wang, KeWei
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936374/
https://ncbi.nlm.nih.gov/pubmed/20796319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-49
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