Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt

BACKGROUND AND PURPOSE: Lipid rafts and caveolae are membrane microdomains with important roles in cell survival signalling involving the Akt pathway. Cholesterol is important for the structure and function of these microdomains. The ginsenoside Rh2 exhibits anti-tumour activity. Because Rh2 is stru...

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Detalhes bibliográficos
Main Authors: Park, E-K, Lee, EJ, Lee, S-H, Koo, KH, Sung, JY, Hwang, EH, Park, JH, Kim, C-W, Jeong, K-C, Park, B-K, Kim, Y-N
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936029/
https://ncbi.nlm.nih.gov/pubmed/20590613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00768.x
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