Tachykinin receptor antagonists inhibit hyperpnea-induced bronchoconstriction in guinea pigs.

We tested the hypothesis that hyperpnea-induced bronchoconstriction (HIB) and hyperpnea-induced bronchovascular hyperpermeability (HIBVH) are mediated through stimulation of NK-1 and NK-2 receptors in guinea pigs. We first established the efficacy and selectivity of (+/-) CP-96,345 (3 mg/kg i.v.) an...

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Pubblicato in:J Clin Invest
Autori principali: Solway, J, Kao, B M, Jordan, J E, Gitter, B, Rodger, I W, Howbert, J J, Alger, L E, Necheles, J, Leff, A R, Garland, A
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 1993
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Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293598/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8392088/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116569
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