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Histamine enhances interleukin (IL)-1-induced IL-1 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. Comparison with IL-1 receptor antagonist.

Histamine and IL-1 have been implicated in the pathogenesis of chronic inflammatory diseases, such as pulmonary allergic reactions and rheumatoid arthritis. We therefore investigated whether histamine modulated the synthesis of IL-1 beta. Human PBMC were stimulated with IL-1 alpha (10 ng/ml) in the...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: Vannier, E, Dinarello, C A
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 1993
Teme:
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293589/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8325995/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116562
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