Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease

Reduced brain levels of docosahexaenoic acid (C22:6n-3), a neurotrophic and neuroprotective fatty acid, may contribute to cognitive decline in Alzheimer's disease. Here, we investigated whether the liver enzyme system that provides docosahexaenoic acid to the brain is dysfunctional in this dise...

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Main Authors: Astarita, Giuseppe, Jung, Kwang-Mook, Berchtold, Nicole C., Nguyen, Vinh Q., Gillen, Daniel L., Head, Elizabeth, Cotman, Carl W., Piomelli, Daniele
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935886/
https://ncbi.nlm.nih.gov/pubmed/20838618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012538
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