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Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders

The reduced expression of the Sp4 gene in Sp4 hypomorphic mice resulted in subtle vacuolization in the hippocampus as well as deficits in sensorimotor gating and contextual memory, putative endophenotypes for schizophrenia and other psychiatric disorders. In this study, we examined both spatial lear...

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Detalhes bibliográficos
Main Authors: Zhou, Xianjin, Nie, Zhiguo, Roberts, Amanda, Zhang, Dongxian, Sebat, Jonathan, Malhotra, Dheeraj, Kelsoe, John R., Geyer, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935857/
https://ncbi.nlm.nih.gov/pubmed/20634195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq298
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