Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase.

Patients with insulin-dependent diabetes (IDDM) possess antibodies to islet proteins of M(r)-64,000. Potential autoantigens of this M(r) include glutamate decarboxylase (GAD) and 65 kD heat shock protein. We have detected two distinct antibody specificities in IDDM that bind 50,000 M(r) or 37,000/40...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Christie, M R, Hollands, J A, Brown, T J, Michelsen, B K, Delovitch, T L
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293578/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8325989/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116556
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