Female human iPS cells retain an inactive X-chromosome

Generating induced pluripotent stem cells (iPSCs) requires massive epigenome reorganization. It is unclear whether reprogramming of female human cells reactivates the inactive X chromosome (Xi), like in mouse. Here we establish that human (h)iPSCs derived from several female fibroblasts under standa...

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Hauptverfasser: Tchieu, Jason, Kuoy, Edward, Chin, Mark H., Trinh, Hung, Patterson, Michaela, Sherman, Sean P., Aimiuwu, Otaren, Lindgren, Anne, Hakimian, Shahrad, Zack, Jerome A., Clark, Amander T., Pyle, April D., Lowry, William E., Plath, Kathrin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935700/
https://ncbi.nlm.nih.gov/pubmed/20727844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.06.024
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