Distinct and separate roles for herpesvirus-conserved UL97 kinase in cytomegalovirus DNA synthesis and encapsidation

The human cytomegalovirus UL97 kinase, an important target of antiviral therapy, has an impact on at least two distinct phases of viral replication. Compared with wild-type virus, the UL97 deletion mutant exhibits an early replication defect that reduces DNA accumulation by 4- to 6-fold, as well as...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Wolf, Dana G., Courcelle, Charmain Tan, Prichard, Mark N., Mocarski, Edward S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11172047/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.98.4.1895
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