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Mechanism of Cadmium Ion Substitution in Mammalian Zinc Metallothionein and Metallothionein Alpha Domain: Kinetic and Structural Studies
Cellular metallothionein (MT) protects against Cd(2+) exposure through direct binding of the metal ion. The model reaction between rabbit liver Zn(7)-MT 2 with Cd(2+) was studied with stopped flow kinetics. Four kinetic steps were observable. Comparison of this reaction with an analogous utilizing M...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2935266/ https://ncbi.nlm.nih.gov/pubmed/20560649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic1003148 |
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