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Defining the pathway to insulin-like growth factor system targeting in cancer
The insulin-like growth factors (IGFs; IGF-1 and IGF-2) play central roles in cell growth, differentiation, survival, transformation and metastasis. The biologic effects of the IGFs are mediated by the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase with homology to the insulin receptor (IR). Dy...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2934757/ https://ncbi.nlm.nih.gov/pubmed/20599789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.06.013 |
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