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A thrombin receptor function for platelet glycoprotein Ib–IX unmasked by cleavage of glycoprotein V

Glycoprotein (GP) V is a major substrate cleaved by the protease thrombin during thrombin-induced platelet activation. Previous analysis of platelets from GP V-null mice suggested a role for GP V as a negative modulator of platelet activation by thrombin. We now report the mechanism by which thrombi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Ramakrishnan, Vanitha, DeGuzman, Francis, Bao, Ming, Hall, Scott W., Leung, Lawrence L., Phillips, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29341/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11172035/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.98.4.1823
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