A thrombin receptor function for platelet glycoprotein Ib–IX unmasked by cleavage of glycoprotein V

Glycoprotein (GP) V is a major substrate cleaved by the protease thrombin during thrombin-induced platelet activation. Previous analysis of platelets from GP V-null mice suggested a role for GP V as a negative modulator of platelet activation by thrombin. We now report the mechanism by which thrombi...

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Bibliografiske detaljer
Main Authors: Ramakrishnan, Vanitha, DeGuzman, Francis, Bao, Ming, Hall, Scott W., Leung, Lawrence L., Phillips, David R.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC29341/
https://ncbi.nlm.nih.gov/pubmed/11172035
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