Ornithine Decarboxylase Antizyme Induces Hypomethylation of Genome DNA and Histone H3 Lysine 9 Dimethylation (H3K9me2) in Human Oral Cancer Cell Line

BACKGROUND: Methylation of CpG islands of genome DNA and lysine residues of histone H3 and H4 tails regulates gene transcription. Inhibition of polyamine synthesis by ornithine decarboxylase antizyme-1 (OAZ) in human oral cancer cell line resulted in accumulation of decarboxylated S-adenosylmethioni...

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Detalhes bibliográficos
Main Authors: Yamamoto, Daisuke, Shima, Kaori, Matsuo, Kou, Nishioka, Takashi, Chen, Chang Yan, Hu, Guo-fu, Sasaki, Akira, Tsuji, Takanori
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933235/
https://ncbi.nlm.nih.gov/pubmed/20838441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012554
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