Aminoflavone, a ligand of the Aryl Hydrocarbon Receptor (AhR), inhibits HIF-1α expression in an AhR-independent fashion

Aminoflavone (AF), the active component of a novel anticancer agent (AFP464) in phase I clinical trials, is a ligand of the aryl hydrocarbon receptor (AhR). AhR dimerizes with HIF-1β/ARNT, which is shared with HIF-1α, a transcription factor critical for the response of cells to oxygen deprivation. T...

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Hlavní autoři: Terzuoli, Erika, Puppo, Maura, Rapisarda, Annamaria, Uranchimeg, Badarch, Cao, Liang, Burger, Angelika M., Ziche, Marina, Melillo, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932848/
https://ncbi.nlm.nih.gov/pubmed/20736373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1075
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