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The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation

Human cytomegalovirus (HCMV) encodes an endoplasmic reticulum (ER)-resident transmembrane glycoprotein, US10, expressed early in the replicative cycle of HCMV as part of the same cluster that encodes the known immunoevasins US2, US3, US6, and US11. We show that US10 down-regulates cell surface expre...

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Bibliografiske detaljer
Main Authors: Park, Boyoun, Spooner, Eric, Houser, Brandy L., Strominger, Jack L., Ploegh, Hidde L.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931171/
https://ncbi.nlm.nih.gov/pubmed/20713594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091793
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