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CD8(+) T-cell immunity against cancer-testis antigens develops following allogeneic stem cell transplantation and reveals a potential mechanism for the graft-versus-leukemia effect

BACKGROUND: Allogeneic stem cell transplantation is associated with a powerful ‘graft-versus-leukemia’ effect that is generally considered to result from an alloreactive T-cell immune response. However, disease remission can also be observed after syngeneic transplantation and we investigated whethe...

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Detalhes bibliográficos
Main Authors: McLarnon, Andrew, Piper, Karen P., Goodyear, Oliver C., Arrazi, Julie M., Mahendra, Premini, Cook, Mark, Clark, Fiona, Pratt, Guy, Craddock, Charles, Moss, Paul. A.H.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930960/
https://ncbi.nlm.nih.gov/pubmed/20460638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.019539
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