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Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts

BACKGROUND: Hematopoietic stem cells are retained within discrete bone marrow niches through the effects of cell adhesion molecules and chemokine gradients. However, a small proportion of hematopoietic stem cells can also be found trafficking in the peripheral blood. During induced stem cell mobiliz...

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Detalhes bibliográficos
Main Authors: Staudt, Nicole D., Aicher, Wilhelm K., Kalbacher, Hubert, Stevanovic, Stefan, Carmona, Adriana K., Bogyo, Matthew, Klein, Gerd
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930944/
https://ncbi.nlm.nih.gov/pubmed/20494937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.018671
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