Development of a Chromosomally Integrated Metabolite-Inducible Leu3p-α-IPM “Off-On” Gene Switch

BACKGROUND: Present technology uses mostly chimeric proteins as regulators and hormones or antibiotics as signals to induce spatial and temporal gene expression. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that a chromosomally integrated yeast ‘Leu3p-α-ΙΡΜ’ system constitutes a ligand-inducible re...

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Autores principales: Poulou, Maria, Bell, Donald, Bozonelos, Kostas, Alexiou, Maria, Gavalas, Anthony, Lovell-Badge, Robin, Remboutsika, Eumorphia
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930855/
https://ncbi.nlm.nih.gov/pubmed/20824215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012488
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