Bromination of deoxycytidine by eosinophil peroxidase: A mechanism for mutagenesis by oxidative damage of nucleotide precursors

Oxidants generated by eosinophils during chronic inflammation may lead to mutagenesis in adjacent epithelial cells. Eosinophil peroxidase, a heme enzyme released by eosinophils, generates hypobromous acid that damages tissue in inflammatory conditions. We show that human eosinophils use eosinophil p...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Henderson, Jeffrey P., Byun, Jaeman, Williams, Michelle V., McCormick, Michael L., Parks, William C., Ridnour, Lisa A., Heinecke, Jay W.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29308/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11172002/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.041146998
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