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The Calcium-binding Protein S100B Down-regulates p53 and Apoptosis in Malignant Melanoma
The S100B-p53 protein complex was discovered in C8146A malignant melanoma, but the consequences of this interaction required further study. When S100B expression was inhibited in C8146As by siRNA (siRNA(S100B)), wt p53 mRNA levels were unchanged, but p53 protein, phosphorylated p53, and p53 gene pro...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930747/ https://ncbi.nlm.nih.gov/pubmed/20587415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155382 |
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