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N348I in HIV-1 Reverse Transcriptase Can Counteract the Nevirapine-mediated Bias toward RNase H Cleavage during Plus-strand Initiation

Drug resistance-associated mutations in HIV-1 reverse transcriptase (RT) can affect the balance between polymerase and ribonuclease H (RNase H) activities of the enzyme. We have recently demonstrated that the N348I mutation in the connection domain causes selective dissociation from RNase H-competen...

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Bibliografiske detaljer
Main Authors: Biondi, Mia J., Beilhartz, Greg L., McCormick, Suzanne, Götte, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930696/
https://ncbi.nlm.nih.gov/pubmed/20530477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105775
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