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Neuron-Restricted Expression of the Rat Gonadotropin-Releasing Hormone Gene Is Conferred by a Cell-Specific Protein Complex that Binds Repeated CAATT Elements

GnRH gene expression is restricted to a tiny population of neurons scattered throughout the mediobasal hypothalamus. The combination of a 300-bp enhancer and the 173-bp promoter from the rat GnRH gene can confer this narrow specificity in transgenic mice and in transfections of hypothalamic GT1–7 ce...

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Détails bibliographiques
Auteurs principaux: Kelley, Carolyn G., Givens, Marjory L., Rave-harel, Naama, Nelson, Shelley B., Anderson, Scott, Mellon, Pamela L.
Format: Artigo
Langue:Inglês
Publié: 2002
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930614/
https://ncbi.nlm.nih.gov/pubmed/12403831
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