A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

The p53 tumor suppressor protein and the MDM2 oncoprotein form a feedback-control loop that up-regulates cellular MDM2 production, blocks p53 activity, and promotes p53 decay. tsg101 was discovered as a gene whose deficiency results in neoplastic transformation of NIH 3T3 cells and the ability to ge...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Li, Limin, Liao, Jian, Ruland, Jürgen, Mak, Tak W., Cohen, Stanley N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2001
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC29306/
https://ncbi.nlm.nih.gov/pubmed/11172000
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk