Structural and Functional Consequences of Poly(ethylene glycol) Inclusion on DNA Condensation For Gene Delivery

Polycationic polymers have been used to condense therapeutic DNA into sub-micron particles, offering protection from shear-induced or enzymatic degradation. However, the spontaneous nature of this self-assembly process gives rise to the formation of multimolecular aggregates, resulting in significan...

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Main Authors: Millili, Peter G., Selekman, Joshua A., Blocker, Kory M., Johnson, David A., Naik, Ulhas P., Sullivan, Millicent O.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930114/
https://ncbi.nlm.nih.gov/pubmed/20232467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jemt.20839
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