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Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line
SNS-032 is a potent inhibitor of cyclin-dependent kinases (Cdk) 2, 7 and 9 that regulate the cell cycle and transcription. Our studies in indolent primary chronic lymphocytic leukemia cells demonstrated that SNS-032 inhibited transcription, diminished the anti-apoptotic protein Mcl-1, and induced ap...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929954/ https://ncbi.nlm.nih.gov/pubmed/20663900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3578 |
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