IL-15 treatment during acute SIV infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses

In this study, we examined the effect of in vivo treatment of acutely SIV infected Mamu-A*01+ rhesus macaques with interleukin 15 (IL-15). IL-15 treatment during acute infection increased viral set point by 3 logs and accelerated the development of simian AIDS in 2 out of 6 animals with one developi...

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Detalhes bibliográficos
Main Authors: Mueller, Yvonne M., Do, Duc H., Altork, Susan R., Artlett, Carol M., Gracely, Edward J., Katsetos, Christos D., Legido, Agustin, Villinger, Francois, Altman, John D., Brown, Charles R., Lewis, Mark G., Katsikis, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929904/
https://ncbi.nlm.nih.gov/pubmed/18097036
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