Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status

Breast cancer is a highly heterogeneous disease, with several different subtypes being characterized by distinct histology, gene expression patterns, and genetic alterations. The tumor suppressor gene retinoblastoma 1 (RB1) is frequently lost in both luminal-B and triple-negative tumor (TNT; i.e., e...

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Main Authors: Jiang, Zhe, Deng, Tao, Jones, Robert, Li, Huiqin, Herschkowitz, Jason I., Liu, Jeff C., Weigman, Victor J., Tsao, Ming-Sound, Lane, Timothy F., Perou, Charles M., Zacksenhaus, Eldad
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2010
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929714/
https://ncbi.nlm.nih.gov/pubmed/20679727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41490
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