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Development of a 2-Aza-Cope-[3+2] Dipolar Cycloaddition Strategy for the Synthesis of Quaternary Proline Scaffolds
[Image: see text] A one-pot multicomponent procedure for the synthesis of highly functionalized pyrrolidine rings through a domino 2-aza-Cope-[3+2] dipolar cycloaddition sequence has been demonstrated. This protocol was found to be both high yielding and stereoselective for the endo-cycloadduct.
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2929309/ https://ncbi.nlm.nih.gov/pubmed/20681608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol101606v |
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