Notch3 in Human Breast Cancer Cell Lines Regulates Osteoblast-Cancer Cell Interactions and Osteolytic Bone Metastasis

Breast cancer preferentially metastasizes to bone. We therefore addressed the role of Notch signaling in osteoblast-cancer cell interactions and in bone metastasis. Human bone marrow osteoblasts selectively enhanced the expression of Notch3 and its ligand Jagged1 in human breast cancer cell lines. O...

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Bibliografiske detaljer
Main Authors: Zhang, Zhiyuan, Wang, Hao, Ikeda, Sadakatsu, Fahey, Frederic, Bielenberg, Diane, Smits, Patrick, Hauschka, Peter V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2010
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928977/
https://ncbi.nlm.nih.gov/pubmed/20651241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090476
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