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Identification of the Bovine Arachnomelia Mutation by Massively Parallel Sequencing Implicates Sulfite Oxidase (SUOX) in Bone Development

Arachnomelia is a monogenic recessive defect of skeletal development in cattle. The causative mutation was previously mapped to a ∼7 Mb interval on chromosome 5. Here we show that array-based sequence capture and massively parallel sequencing technology, combined with the typical family structure in...

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Autors principals: Drögemüller, Cord, Tetens, Jens, Sigurdsson, Snaevar, Gentile, Arcangelo, Testoni, Stefania, Lindblad-Toh, Kerstin, Leeb, Tosso
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928811/
https://ncbi.nlm.nih.gov/pubmed/20865119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001079
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