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Epistasis: Obstacle or Advantage for Mapping Complex Traits?

Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype. There is mounting evidence that locus interactions, or epistasis, are a crucial component of the genetic architecture of biologica...

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Bibliografiske detaljer
Main Authors: Verhoeven, Koen J. F., Casella, George, McIntyre, Lauren M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928725/
https://ncbi.nlm.nih.gov/pubmed/20865037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012264
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