CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response

The extracellular signal-regulated kinase (ERK) pathway is an important signalling pathway that regulates a large number of cellular processes, including proliferation, differentiation and gene expression. Hyperosmotic stress activates the ERK pathway, whereas little is known about the regulatory me...

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Hauptverfasser: Maruyama, Takeshi, Kadowaki, Hisae, Okamoto, Noriaki, Nagai, Atsushi, Naguro, Isao, Matsuzawa, Atsushi, Shibuya, Hiroshi, Tanaka, Keiji, Murata, Shigeo, Takeda, Kohsuke, Nishitoh, Hideki, Ichijo, Hidenori
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928693/
https://ncbi.nlm.nih.gov/pubmed/20588253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.141
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