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Genome-wide mapping of nuclear mitochondrial DNA sequences links DNA replication origins to chromosomal double-strand break formation in Schizosaccharomyces pombe

Chromosomal double-strand breaks (DSBs) threaten genome integrity and repair of these lesions is often mutagenic. How and where DSBs are formed is a major question conveniently addressed in simple model organisms like yeast. NUMTs, nuclear DNA sequences of mitochondrial origin, are present in most e...

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Autori principali: Lenglez, Sandrine, Hermand, Damien, Decottignies, Anabelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928503/
https://ncbi.nlm.nih.gov/pubmed/20688779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.104513.109
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