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A Crohn’s disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
A common mutation in the gene encoding the cytoplasmic sensor Nod2, involving a frameshift insertion at nucleotide 3020 (3020insC), is strongly associated with Crohn’s disease. How 3020insC contributes to this disease is a controversial issue. Clinical studies have identified defective production of...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928218/ https://ncbi.nlm.nih.gov/pubmed/19349988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1722 |
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