Experimental Treatment of Estrogen Receptor (ER) Positive Breast Cancer with Tamoxifen and Brivanib Alaninate, a VEGFR-2/FGFR-1 Kinase Inhibitor: a potential clinical application of angiogenesis inhibitors

PURPOSE: Tamoxifen, a selective estrogen receptor modulator (SERM), and brivanib alaninate, a VEGFR-2 inhibitor, are two target specific agents that result in a substantial decrease in tumor growth when given alone. Tamoxifen activates SERM stimulated breast and endometrial tumor growth. Tamoxifen a...

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Main Authors: Patel, Roshani R, Sengupta, Surojeet, Kim, Helen R., Klein-Szanto, Andres J., Pyle, Jennifer R., Zhu, Fang, Li, Tianyu, Ross, Eric A., Oseni, Salewa, Fargnoli, Joseph, Jordan, V. Craig
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927957/
https://ncbi.nlm.nih.gov/pubmed/20303261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2010.02.018
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