Local Expression of Indoleamine 2,3 Dioxygenase in Syngeneic Fibroblasts Significantly Prolongs Survival of an Engineered Three-Dimensional Islet Allograft

OBJECTIVE: The requirement of systemic immunosuppression after islet transplantation is of significant concern and a major drawback to clinical islet transplantation. Here, we introduce a novel composite three-dimensional islet graft equipped with a local immunosuppressive system that prevents islet...

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Main Authors: Jalili, Reza B., Forouzandeh, Farshad, Rezakhanlou, Alireza Moeen, Hartwell, Ryan, Medina, Abelardo, Warnock, Garth L., Larijani, Bagher, Ghahary, Aziz
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2010
Assuntos:
Immunology and Transplantation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927944/
https://ncbi.nlm.nih.gov/pubmed/20522587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1560
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