Oral Tetrahydrobiopterin Improves the Beneficial Effect of Adenoviral-mediated eNOS Gene Transfer After Induction of Hindlimb Ischemia

We tested the hypothesis that oral supplementation with the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH(4)) improved the therapeutic efficacy of eNOS gene transfer in the ischemic rat hindlimb. BH(4) or vehicle were begun 1 week before induction of hindlimb ischemia, wh...

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Detalhes bibliográficos
Principais autores: Yan, Jinglian, Tie, Guodong, Hoffman, Ari, Yang, Yagai, Nowicki, Philip T, Messina, Louis M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927060/
https://ncbi.nlm.nih.gov/pubmed/20551918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.109
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