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Optimizing Combination Therapies with Existing and Future CML Drugs

Small-molecule inhibitors imatinib, dasatinib and nilotinib have been developed to treat Chromic Myeloid Leukemia (CML). The existence of a triple-cross-resistant mutation, T315I, has been a challenging problem, which can be overcome by finding new inhibitors. Many new compounds active against T315I...

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Detalhes bibliográficos
Main Authors: Katouli, Allen A., Komarova, Natalia L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925944/
https://ncbi.nlm.nih.gov/pubmed/20808800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012300
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