Bortezomib, tacrolimus, and methotrexate for prophylaxis of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation from HLA-mismatched unrelated donors

Graft-versus-host disease (GVHD) is a significant complication of allogeneic stem cell transplantation (alloSCT). The proteasome inhibitor bortezomib has immunomodulatory properties of potential benefit for GVHD control. We undertook a phase 1 trial of bortezomib, tacrolimus, and methotrexate for GV...

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Detalhes bibliográficos
Main Authors: Koreth, John, Stevenson, Kristen E., Kim, Haesook T., Garcia, Michael, Ho, Vincent T., Armand, Philippe, Cutler, Corey, Ritz, Jerome, Antin, Joseph H., Soiffer, Robert J., Alyea, Edwin P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925723/
https://ncbi.nlm.nih.gov/pubmed/19713456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-231092
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